Changes in freeway level of service with the introduction of autonomous and connected vehicles

Connected and Autonomous vehicles (CAVs) have risen in popularity in recent years and are expected to bring with them many changes including driver safety, expansion of ridership from people currently unable to drive, and more travel miles from long trip commuters. From an engineering standpoint, CAVs are expected to bring with them an increase in highway capacities because of their ability to react faster than human drivers and produce shorter time headways between successive vehicles. CAVs are not anticipated to dominate the traffic stream until another 20 to 40 years and are expected to be introduced gradually into the transportation system. Shorter time headways suggest that freeways may be positively affected by the new technology and new procedures will need to be established in order to analyze highway capacities in the future. The 6th Edition Highway Capacity Manual is one of the main sources that is used by the engineering community to estimate capacities of freeway segments. This study documents a new simulation tool to discover the capacity implications for a basic freeway segment of different CAV market penetrations and reduced time headwaysCivil, Architectural, and Environmental Engineerin

Optimización del proceso de retención del call center corporativo de Nextel del Perú

Las empresas de hoy en día, enfocan gran cantidad de sus recursos y esfuerzos en tratar de satisfacer las necesidades y deseos de sus clientes. El atraer nuevos clientes, involucra por lo general, un mayor esfuerzo, tanto en planeamiento y ejecución como en utilización -de recursos. El utilizar estos recursos escasos de manera eficiente, requiere como pilar central, el identificar y valorar los clientes, tanto los actuales como los potenciales. El valor de un cliente, en relación con otros clientes, permite a la empresa priorizar esfuerzos y dedicar más recursos para conseguir que los clientes más valiosos sigan siendo leales permitiendo que fruto de esa relación empresa-cliente, la empresa crezca y aumente su valor. Satisfacer las expectativas del cliente, es la base para establecer una buena relación y ganarse su lealtad.Tesi

The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis

Circadian clock is known to adapt to environmental changes and can significantly influence cognitive and physiological functions. In this work, we report specific behavioral, cognitive, and sleep homeostatic defects in the after hours (Afh) circadian mouse mutant, which is characterized by lengthened circadian period. We found that the circadian timing irregularities in Afh mice resulted in higher interval timing uncertainty and suboptimal decisions due to incapability of processing probabilities. Our phenotypic observations further suggested that Afh mutants failed to exhibit the necessary phenotypic plasticity for adapting to temporal changes at multiple time scales (seconds-to- minutes to circadian). These behavioral effects of Afh mutation were complemented by the specific disruption of the Per/Cry circadian regulatory complex in brain regions that govern food anticipatory behaviors, sleep, and timing. We derive statistical predictions, which indicate that circadian clock and sleep are complementary processes in controlling behavioral/cognitive performance during 24 hrs. The results of this study have pivotal implications for understanding how the circadian clock modulates sleep and behavior

A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease

The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases such as obesity, diabetes, cancer and also neurodegenerative disease, such as Parkinson, Huntington and Alzheimer's disease (AD), although whether causative, consequence or merely an epiphenomenon is still under investigation. In the present study, we performed a metabologenomic analysis of stool samples from a mouse model of AD, the 3xTgAD. We found a significant change in the microbiota of AD mice compared to WT, with a longitudinal divergence of the F/B ratio, a parameter suggesting a gut dysbiosis. Moreover, AD mice showed a significant decrease of some amino acids, while data integration revealed a dysregulated production of desaminotyrosine (DAT) and dihydro-3-coumaric acid. Collectively, our data show a dysregulated gut microbiota associated to the onset and progression of AD, also indicating that a dysbiosis can occur prior to significant clinical signs, evidenced by early SCFA alterations, compatible with gut inflammation